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KMID : 0352119930090020195
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Journal of Kyung Hee University
1993 Volume.9 No. 2 p.195 ~ p.202
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Response of Shuigou(GV 26). Stimulation on Cerebral Blood flow in the Middle Cerebral Artery Occlusion Rats
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Abstract
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The aim of this study was to investigate the effects of electrical stimulation of Shuigou point on the blood pressure and regional cerebral blood flow in middle cerebral artery occlusion rats. 25 Sprague-Dawley rats weighing 280~340g were used in
both
sex. Rats were anesthetized with 4% halothane in 70:30 mixture N2O and O2 rapidly in the anesthetizing box and then anesthesia was maintained with urethane 80 mg/Kg intraperitoneally. Animals were divided into two groups, that is, sham group
(N=7)
and
sample group (N=18). To stimulate the Shuigou point in sample group, bipolar stainless-steel electrodes were used. Stimulus parameter was 0.8 mA 5 ms 100Hz. The duration of stimulation was 10 minites. Its responses were determined at 5 min and 10
mini
after stimulation. Blood pressure was monitored in physiogarphy (Grass model 79E) with statham tranducer connected into right femoral artery. Cerebral blood flow was measured using the hydrogen clearance technique.
In sham group, there were no significant changes in blood pressure and cerebral blood flow. In sample group. 0.8 mA 5 ms 100 Hz electrical stimultion were able to increase blood pressure significantly by average 21% (p<0.01, respectively) at 5
min
and
10 min as compared with prior to stimulation Differences between at 5 min and 10 min of stimulation were not appeared. But comparision of intergroup at 5 min and 10 min showed significant differences (p<0.05, respectively). As to the cerebral
blood
flow, there were no changes in the ipsilateral side of infarcted hemisphere after stimulation. But cerebral blood flow increased from 55.1±13.0 ml/100g/min of pre-stimulation to 67.4±15.1 ml/100g/min, average 24% of increasement (p<0.01) at 5
min
and
to 64.7±18.8 ml/100g/min, average 19% (p<0.01) at 10 min of stimulation in contralateral hemisphere. Although differences between 5 min and 10 min of stimulation were not appeared in sample group, comparision of intergroup at 5 min and 10 min
showed
significant differences (p<0.05, respectively).
From the above results, it might be suggested that acupuncture treatment on shuigou point will induce the change of cerebral blood flow in the cerebral ischemia or/and infarction and further study would be needed.
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KEYWORD
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